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Schwann cell CD9 expression is regulated by axons

S A Banerjee1, P H Patterson

  • 1Biology Division, California Institute of Technology, Pasadena 91125, USA.

Molecular and Cellular Neurosciences
|October 1, 1995
PubMed
Summary

Schwann cell CD9 expression is controlled by axonal contact during nerve development and regeneration. This cell-surface glycoprotein

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • CD9, a cell-surface glycoprotein, plays a role in hematopoietic and Schwann cell signaling.
  • Schwann cell CD9 expression in vivo mirrors the developmental timeline of myelin genes.

Purpose of the Study:

  • To investigate the regulation of Schwann cell CD9 mRNA expression by axonal contact.
  • To determine the role of CD9 in nerve development and regeneration.

Main Methods:

  • Analysis of CD9 mRNA expression in rat sciatic nerve sections following injury.
  • Culture of Schwann cells with and without sensory neurons to assess CD9 regulation.

Main Results:

  • Schwann cell CD9 mRNA expression is regulated by axonal contact both in vivo and in vitro.
  • CD9 expression decreases during axonal degeneration and increases during regeneration.
  • Dissociated Schwann cells down-regulate CD9, but expression is maintained in the presence of neurons.

Conclusions:

  • Axonal contact is a key regulator of Schwann cell CD9 expression.
  • CD9 regulation parallels that of myelin genes, suggesting a role in myelination.
  • A signaling function for CD9 in nerve development and regeneration is proposed.

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