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Synthesis and conformational analysis of pyrimidine nucleoside analogues with a rigid sugar moiety
M Björsne1, T Szabó, B Samuelsson
1Department of Organic Chemistry, Stockholm University, Sweden.
Bioorganic & Medicinal Chemistry
|April 1, 1995
Abstract:
In order to obtain rigidity within the sugar moiety of nucleosides, some bicyclic pyrimidine nucleoside analogues were synthesized starting from cyclopentanone. The C-3' is fused to C-4' via a propylene linker in order to obtain a [3.3.0]-bicyclic ring system wherein the sugar moiety should be restricted to mainly the C-1'-exo conformation.