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[Effects of verapamil on left ventricular diastolic dysfunction]

J Fan1, Y Zhang, M Zhang

  • 1Department of Cardiology, Affiliated Hospital, Shandong Medical University, Jinan.

Zhonghua Nei Ke Za Zhi
|June 1, 1995
PubMed

Insights

Verapamil improved left ventricular filling in patients with diastolic dysfunction. However, relaxation improvements varied by condition, suggesting verapamil

Area of Science:

  • Cardiology
  • Pharmacology

Context:

  • Left ventricular diastolic dysfunction (LVDD) affects cardiac filling and relaxation.
  • Assessing pharmacological interventions for LVDD is crucial for patient outcomes.

Purpose:

  • To evaluate the impact of verapamil on left ventricular relaxation and filling dynamics in LVDD patients.
  • To differentiate verapamil's effects based on the etiology of LVDD.

Summary:

  • Simultaneous Doppler echocardiography and cardiac catheterization were used in 30 LVDD patients before and after verapamil administration.
  • Verapamil significantly enhanced left ventricular filling across all patients.
  • Left ventricular relaxation improved in hypertrophic cardiomyopathy and hypertensive heart disease but not in old myocardial infarction, with no correlation between filling and relaxation indices.

Impact:

  • Verapamil's primary mechanism for improving left ventricular filling appears to be afterload reduction.
  • Therapeutic effects of verapamil in LVDD are etiology-dependent.
  • Findings guide personalized verapamil treatment strategies for diverse LVDD patient populations.

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