Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dysphoric mania and mixed states]

M Bourgeois1, H Verdoux, C H Mainard

  • 1IPSO, Université de Bordeaux II.

L'Encephale
|December 1, 1995
PubMed
Summary

Mixed states in bipolar disorder are common, severe, and challenging to treat. Anticonvulsant medications show greater efficacy than lithium, with electroconvulsive therapy (ECT) as a potential option for non-responsive cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effectiveness of peer helper interventions for people with schizophrenia or bipolar disorder: A literature review].

L'Encephale·2022
Same author

Maternal post-natal depressive symptoms at 2 months: Effects of French antenatal preventive measures in the E.L.F.E. cohort.

Journal of affective disorders·2021
Same author

Being parent is associated with suicidal history in people with serious mental illness enrolled in psychiatric rehabilitation.

Journal of psychiatric research·2021
Same author

Stigma resistance is associated with advanced stages of personal recovery in serious mental illness patients enrolled in psychiatric rehabilitation.

Psychological medicine·2020
Same author

Educational needs and psychoeducation interventions in clozapine users: a narrative review.

Acta psychiatrica Scandinavica·2020
Same author

[Electroconvulsive therapy in combination with psychotropic and non-psychotropic pharmacological treatments: Review of the literature and practical recommendations].

L'Encephale·2020

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Context:

  • Mixed states, including depressive or dysphoric mania, represent a significant subtype of bipolar disorder, frequently observed and posing treatment challenges.
  • Historically described by Kraepelin, these conditions are now a renewed focus of clinical research due to their prevalence (30-40%) and severity.

Purpose:

  • To review the clinical characteristics, treatment options, and ongoing debates regarding the nature and physiopathogeny of mixed states in bipolar disorder.
  • To highlight the distinct therapeutic responses observed in patients experiencing mixed states compared to pure mania.

Summary:

  • Mixed states are prevalent (30-40%) and severe forms of bipolar disorder, often associated with comorbid conditions like neurological disorders and substance abuse.
  • Patients with mixed states demonstrate reduced responsiveness to lithium but appear to benefit more from anticonvulsant drugs, which can be co-prescribed with lithium.
  • Electroconvulsive therapy (ECT) is a viable treatment for cases unresponsive to pharmacological interventions.

Impact:

  • Findings underscore the need for tailored treatment strategies for mixed states, potentially involving anticonvulsants and ECT.
  • This research contributes to understanding the complex nature of mixed states, differentiating them from pure mania and informing future etiological investigations.
  • Improved management of mixed states can lead to better patient outcomes and reduced healthcare burden associated with severe bipolar disorder.

Related Experiment Videos