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Platelet size and left ventricular hypertrophy in hypertensive patients over 50 years of age

A Scuteri1, M Cacciafesta, A M de Propris

  • 1Cattedra Gerontologia e Geriatria, Universita' di Roma La Sapienza, Policlinico Umberto I, I Clinica Medica, Rome, Italy.

European Journal of Clinical Investigation
|November 1, 1995
PubMed

Insights

Mean platelet volume (MPV) is linked to left ventricular hypertrophy (LVH) in hypertensive patients over 50. Higher MPV was observed in patients with LVH, suggesting a potential association with cardiac structural changes.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Mean platelet volume (MPV) and left ventricular hypertrophy (LVH) are risk factors for vascular events.
  • Hypertension is a major contributor to cardiovascular disease and structural heart changes.

Purpose of the Study:

  • To investigate the association between MPV and LVH in hypertensive patients.
  • To determine if MPV correlates with markers of cardiac structural changes in this population.

Main Methods:

  • Seventy-six hypertensive patients over 50 years old were studied.
  • LVH was assessed using M-mode echocardiography (LV mass index > 125 g m-2).
  • MPV was measured and correlated with LV mass index and interventricular septum thickness.

Main Results:

  • MPV was higher in hypertensive patients with LVH compared to those without (P > 0.05).
  • MPV showed a significant association with the occurrence of LVH (chi-square = 8.44, P = 0.042).
  • MPV significantly correlated with left ventricular mass index (r = 0.298, P = 0.004) and interventricular septum thickness (r = 0.231, P = 0.022), even after adjustments.

Conclusions:

  • MPV is associated with increased left ventricular mass and interventricular septum thickness in middle-aged to elderly hypertensive patients.
  • These findings suggest MPV may serve as a potential biomarker for cardiac structural alterations in hypertension.

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