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Corticosteroid-binding globulin in preterm infants in an intensive care unit

S M Scott1, L Wells

  • 1Department of Pediatrics, Children's Hospital of New Mexico, University of New Mexico School of Medicine, Albuquerque 87123-5311, USA.

Hormone Research
|January 1, 1995
PubMed

Insights

Corticosteroid-binding globulin (CBG) levels in preterm infants increase with age. Lower CBG concentrations were observed in infants with pulmonary disease, suggesting a link to inflammation.

Area of Science:

  • Neonatal Medicine
  • Endocrinology
  • Pediatric Pulmonology

Background:

  • Corticosteroid-binding globulin (CBG) plays a crucial role in regulating corticosteroid bioavailability.
  • Understanding CBG dynamics in preterm infants is essential for assessing physiological development and disease states.

Purpose of the Study:

  • To investigate the changes in blood corticosteroid-binding globulin (CBG) concentrations in preterm infants during the first six weeks of life.
  • To determine the correlation between CBG levels, gestational age, postnatal age, and the presence of pulmonary disease.

Main Methods:

  • Blood samples were collected from 85 preterm infants (24-36 weeks gestational age) over the first 6 weeks of postnatal life.
  • CBG concentrations were measured and analyzed in relation to gestational age and postnatal age.
  • Statistical analysis was performed to compare CBG levels between infants with and without pulmonary disease.

Main Results:

  • CBG concentrations showed a direct correlation with both gestational age and postnatal age within the first week of life.
  • A significant increase in mean CBG values was observed from weeks 1-2 to weeks 4-6.
  • Infants experiencing pulmonary disease in the first week exhibited significantly lower postnatal CBG values (p = 0.001).

Conclusions:

  • CBG levels in preterm infants are influenced by both gestational and postnatal age.
  • Lower CBG concentrations in infants with pulmonary disease may indicate an inflammatory response.
  • These findings highlight the potential of CBG as a biomarker in neonatal critical care.

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