Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimizing ultrasound focus distributions for hyperthermia

R J Lalonde1, J W Hunt

  • 1Hamilton Regional Cancer Centre, Ontario, Canada.

IEEE Transactions on Bio-Medical Engineering
|October 1, 1995
PubMed
Summary

This study introduces a novel method for ultrasound hyperthermia treatment planning. It optimizes ultrasound focus patterns to precisely control tumor temperatures, enhancing therapeutic effectiveness and safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unbecoming a Gentleman.

The Dental register·2021
Same author

The influence of oxygen and peroxides on the response of mammalian cells and tissues to ionizing radiations.

Progress in nuclear energy. Series 6 Biological sciences·2014
Same author

Life before death.

Proceedings of the Royal Society of Medicine·2010
Same author

A novel mechanism by which silica defends grasses against herbivory.

Annals of botany·2008
Same author

Tissue ultrasound absorption measurement with MRI calorimetry.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2008
Same author

The source and distribution of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofurans in sediments of Port Jackson, Australia.

Marine pollution bulletin·2006

Area of Science:

  • Medical Physics
  • Biomedical Engineering
  • Oncology

Background:

  • Ultrasound hyperthermia offers a non-invasive approach to cancer treatment.
  • Accurate temperature control within tumors is crucial for efficacy and minimizing damage to surrounding tissues.
  • Current treatment planning methods require optimization for complex thermal distributions.

Purpose of the Study:

  • To develop and describe a method for generating optimal ultrasound focus patterns for hyperthermia treatment planning.
  • To incorporate specific temperature constraints for both tumor boundaries and interior.
  • To provide a computational framework for precise thermal dose delivery.

Main Methods:

  • A novel method for determining the placement and intensity of ultrasound focus points.
  • Utilizing equality constraints on the tumor boundary (maximum safe temperature).
  • Employing inequality constraints within the tumor interior (therapeutic temperature range).
  • Solving a series of linear equations using a simplex algorithm to approximate tissue heating.
  • Application of field conjugate acoustic lens applicators for multi-foci generation.

Main Results:

  • The described method successfully generates ultrasound focus patterns tailored to specific temperature constraints.
  • The simplex algorithm effectively approximates the heating distribution in biological tissues.
  • Field conjugate acoustic lens applicators demonstrate capability for simultaneous multi-foci generation, enabling complex thermal profiles.

Conclusions:

  • The developed method provides an effective approach for ultrasound hyperthermia treatment planning.
  • This technique allows for precise temperature management, crucial for optimizing therapeutic outcomes.
  • The findings support the advancement of non-invasive cancer treatment technologies through improved planning and delivery.

Related Experiment Videos