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Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of
A Hoek1, F J Broekmans, R H Verheijen
1Department of Obstetrics and Gynaecology, Free University Hospital, Amsterdam, The Netherlands.
Human Reproduction (Oxford, England)
|July 1, 1995
Abstract:
A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4 x 50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.