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Updated: Aug 6, 2026

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Published on: January 7, 2019
Long-term efficacy of a new formulation of prostaglandin E1 as treatment for erectile failure
M Godschalk1, D Gheorghiu, J Chen
1Division of Geriatrics Medicine, Medical College of Virginia, McGuire Veterans Affairs Medical Center, Richmond, USA.
Purpose:
We determined the long-term efficacy of intracavernous injection of a new formulation of prostaglandin E1 (Caverject) as treatment for erectile failure.
Materials And Methods:
A prospective study was done at a university affiliated Veterans Affairs medical center. Subjects with erectile failure received injections of prostaglandin E1 at the office and self-administered injections at home for up to 18 months.
Results:
Of 16 patients who performed home injections 15 completed 6 months and 10 completed 18 months of therapy. Patient and spousal satisfaction with intercourse was 90% for months 1 to 6, and patient satisfaction was 95% for months 7 to 18.
Conclusions:
Prostaglandin E1 was highly effective at producing penile rigidity and an erection with satisfactory vaginal intercourse.
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