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Ameliorative effect of allopurinol on nonbacterial prostatitis: a parallel double-blind controlled study
B E Persson1, G Ronquist, M Ekblom
1Department of Urology, University Hospital, Uppsala, Sweden.
The Journal of Urology
|March 1, 1996
Summary
Allopurinol significantly improves symptoms of nonbacterial prostatitis by reducing urate levels. This safe treatment is recommended for at least three months to manage recurrent episodes effectively.
Area of Science:
- Urology
- Pharmacology
Background:
- Nonbacterial prostatitis is a common, recurrent condition in young men, often lasting months.
- Potential causes include microorganisms, stones, psychological factors, and urinary reflux into prostatic ducts.
- Previous research linked urinary reflux to prostatic pain and urate concentration.
Purpose of the Study:
- To evaluate the objective and subjective effects of allopurinol in patients with nonbacterial prostatitis.
- To assess the impact of allopurinol on urate and xanthine concentrations and patient-reported discomfort.
Main Methods:
- A parallel, double-blind, placebo-controlled study was conducted.
- 18 patients received 300 mg allopurinol daily, 16 received 600 mg daily, and 20 received placebo for 240 days.
- No adverse effects were reported in any treatment group.
Main Results:
- Allopurinol demonstrated significant effects on serum urate, urine urate, and expressed prostatic secretion urate concentrations.
- A notable reduction in expressed prostatic secretion xanthine was observed.
- Subjective patient discomfort showed significant improvement.
Conclusions:
- Allopurinol has a significant positive effect on nonbacterial prostatitis.
- The treatment is safe and recommended for a trial of at least three months per episode.
- Allopurinol effectively relieves symptoms associated with nonbacterial prostatitis.