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Published on: October 24, 2016
Mast cell tumour destruction in dogs by hypotonic solution
R L Grier1, G Di Guardo, R Myers
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011, USA.
The Journal of Small Animal Practice
|September 1, 1995
Summary
Distilled water injections after surgery significantly reduced mast cell tumor recurrence in dogs. Small tumors injected with distilled water alone also regressed, suggesting its potential as an oncolysis agent.
Area of Science:
- Veterinary Medicine
- Oncology
- Surgical Research
Background:
- Mast cell tumors (MCTs) are common in dogs and can recur after surgical removal.
- Preventing MCT recurrence is crucial for improving patient outcomes.
- Hypoosmotic agents are being explored for their potential anti-tumor effects.
Purpose of the Study:
- To evaluate distilled water as a hypoosmotic oncolysis agent.
- To determine if distilled water can prevent MCT recurrence post-surgery.
- To assess the efficacy of distilled water on non-surgically treated small MCTs.
Main Methods:
- A study involving 118 MCTs in 74 dogs.
- Comparison of surgery alone versus surgery followed by distilled water injections.
- Direct injection of distilled water into 10 small, non-surgically treated MCTs.
Main Results:
- Surgery alone had a 52.6% MCT recurrence rate.
- Surgery with distilled water injections reduced recurrence to 26.2%.
- All 10 small MCTs treated with distilled water alone showed complete regression.
Conclusions:
- Distilled water demonstrates potential as an oncolysis agent for canine MCTs.
- Using distilled water as an adjunct to surgery may decrease MCT recurrence rates.
- Further investigation into distilled water as a treatment for canine MCTs is warranted.
