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Postural stability among manganese exposed workers

S E Chia1, S L Gan, L H Chua

  • 1Department of Community, Occupational and Family Medicine, National University of Singapore, Republic of Singapore.

Neurotoxicology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Manganese-exposed workers show poorer postural stability, especially with eyes closed. This may indicate subclinical effects on the basal ganglia, impacting balance control even without clear links to current manganese levels.

Area of Science:

  • Neuroscience
  • Occupational Health
  • Biomedical Engineering

Background:

  • Occupational exposure to manganese can lead to neurological deficits.
  • Assessing subclinical effects of manganese on postural stability is crucial for early detection.

Purpose of the Study:

  • To investigate postural stability in manganese-exposed workers compared to a referent group.
  • To explore the relationship between manganese exposure duration and postural sway.
  • To examine the impact of visual input on postural control in exposed individuals.

Main Methods:

  • Static posturography was employed to measure postural sway in 32 manganese-exposed workers and 53 referent subjects.
  • Postural parameters were assessed under eyes-open and eyes-closed conditions.

Related Experiment Videos

  • Romberg Ratios were calculated to evaluate the effect of visual deprivation on postural stability.

    • Main Results:

    • Manganese-exposed workers exhibited significantly poorer postural stability, particularly in sway path length (L) and center of pressure velocity (Vel).
    • Romberg Ratios for Vel, L, and Ao (area of sway) differed significantly between exposed and referent groups, indicating impaired sensory reweighting.
    • No significant association was found between current urinary manganese concentrations and postural sway parameters.

    Conclusions:

    • Manganese-exposed workers demonstrate compromised postural stability, suggesting potential subclinical neurotoxicity affecting the basal ganglia.
    • The observed deficits are more pronounced under conditions of reduced visual input, highlighting impaired sensory integration.
    • Current urinary manganese levels may not accurately reflect long-term exposure or its neurological impact on balance.