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Related Experiment Videos

Self assembling nanostructures for sustained ophthalmic drug delivery

A J Khopade1, N K Jain

  • 1Department of Pharmaceutics, Bharati Vidyapeeth's Poona College of Pharmacy, Pune, India.

Die Pharmazie
|December 1, 1995
PubMed
Summary

New nanopseudolatex formulations offer sustained ophthalmic drug delivery. This approach enhances therapeutic efficacy for conditions like eye inflammation compared to traditional eye drops.

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Area of Science:

  • Ophthalmic drug delivery
  • Nanotechnology
  • Polymer science

Background:

  • Sustained ophthalmic drug delivery is crucial for improving therapeutic outcomes and patient compliance.
  • Conventional eye drops offer limited drug retention time and require frequent administration.
  • Acrylate copolymers like Eudragit RLPM and RSPM are suitable for developing drug delivery systems.

Purpose of the Study:

  • To develop a novel nanopseudolatex formulation for sustained ophthalmic delivery of diclofenac diethyl ammonium.
  • To characterize the physicochemical and pharmacodynamic properties of the prepared nanopseudolatex.
  • To evaluate the therapeutic efficacy of the new formulation compared to conventional eye drops.

Main Methods:

  • Nanopseudolatex preparation via solvent injection without stabilizers.

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  • Carrier materials: Eudragit RLPM and Eudragit RSPM.
  • Characterization: electron microscopy, particle size, viscosity, sedimentation, encapsulation efficiency, in vitro release, and pharmacodynamics.

    • Main Results:

    • Nanopseudolatex formation confirmed by electron microscopy.
    • Particle size dependent on stirring rate; temperature dependent at slow rates.
    • No sedimentation observed for 60 days.
    • High encapsulation efficiency (94-98%) achieved.
    • Slow and consistent drug release observed, with Eudragit RSPM showing longer release than Eudragit RLPM.
    • Diclofenac diethyl ammonium formulation demonstrated increased therapeutic efficacy.

    Conclusions:

    • A stabilizer-free nanopseudolatex system for sustained ophthalmic delivery was successfully developed.
    • The formulation exhibits excellent encapsulation efficiency and controlled drug release.
    • The developed nanopseudolatex formulation offers enhanced therapeutic efficacy over traditional eye drops.