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Related Experiment Video

Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

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Ischemic bowel disease attributable to ergot

A E Stillman, M Weinberg, W C Mast

    Gastroenterology
    |June 1, 1977
    PubMed
    Summary

    Ergotamine tartrate overdose can cause ischemic colitis, a serious bowel condition. This case study highlights a patient who developed this rare complication without predisposing health factors.

    Area of Science:

    • Gastroenterology
    • Toxicology
    • Vascular Medicine

    Background:

    • Ischemic colitis is a serious condition affecting the colon.
    • Ergotamine tartrate is a medication used for migraines.
    • Bowel ischemia can have various causes, including vascular issues.

    Observation:

    • A 50-year-old woman experienced ischemic colitis.
    • The colitis onset was temporally linked to the ingestion of a large dose of ergotamine tartrate.

    Findings:

    • The patient had no pre-existing cardiovascular, metabolic, or inflammatory conditions that typically predispose individuals to bowel ischemia.
    • This case represents the first documented instance of bowel ischemia proven to be secondary to ergot toxicity.

    Implications:

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    • This case underscores the potential for ergotamine tartrate toxicity to induce gastrointestinal ischemia.
    • Clinicians should consider ergot toxicity in the differential diagnosis of ischemic colitis, particularly in patients with high-dose ergotamine tartrate exposure.
    • Further research may be warranted to elucidate the mechanisms underlying ergot-induced bowel ischemia.