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Updated: Aug 19, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

In vivo neutralization of tetrodotoxin by a monoclonal antibody

K Matsumura1

  • 1Yamaguchi Prefectural Research Institute of Health, Japan.

Toxicon : Official Journal of the International Society on Toxinology
|September 1, 1995
PubMed

This study examined the ability of monoclonal antibody against TTX to neutralize tetrodotoxin (TTX) in vivo. The mice were injected i.p. with 1.5 mouse units of TTX, followed 3 min later by administering graded doses of antibody immunoglobulin G (IgG). Animals injected with 100 micrograms IgG through the tail vein showed 100% survival. The 50% protective dose was c. 2 mg/kg. The present results indicate that monoclonal antibody can neutralize TTX in vivo.

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