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Pharmacokinetic interaction between lansoprazole and theophylline
G R Granneman1, M D Karol, C S Locke
1Drug Metabolism Department, Abbott Laboratories, Abbott Park, Illinois 6064-3500, USA.
Therapeutic Drug Monitoring
|October 1, 1995
Summary
This study investigated lansoprazole and theophylline drug interactions. Lansoprazole did not significantly alter theophylline absorption or clearance, suggesting minimal clinical impact.
Area of Science:
- Pharmacokinetics
- Drug Interactions
- Gastroenterology
Background:
- Proton-pump inhibitors (PPIs) like lansoprazole are widely used.
- Theophylline is a medication with a narrow therapeutic index.
- Assessing PPI-drug interactions is crucial for patient safety.
Purpose of the Study:
- To evaluate the pharmacokinetic interaction between lansoprazole and theophylline.
- To determine if lansoprazole affects theophylline absorption, distribution, metabolism, or excretion.
Main Methods:
- A double-blind, placebo-controlled, crossover study was conducted.
- 14 healthy male volunteers received lansoprazole or placebo with theophylline.
- Plasma theophylline concentrations were measured using high-performance liquid chromatography.
Main Results:
- Lansoprazole did not substantially affect theophylline absorption or clearance.
- A statistically significant, but small (13%), decrease in theophylline's area under the curve was observed.
- No significant impact on theophylline's pharmacokinetic profile was noted.
Conclusions:
- The coadministration of lansoprazole with theophylline is unlikely to cause clinically significant pharmacokinetic interactions.
- Lansoprazole appears to be safe for concurrent use with theophylline in healthy individuals.