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Cranial MR in Wilson disease: abnormal white matter in extrapyramidal and pyramidal tracts
H N van Wassenaer-van Hall1, A G van den Heuvel, G H Jansen
1Department of Radiology, University Hospital Utrecht, The Netherlands.
Purpose:
To describe abnormal white matter in the brain on MR in Wilson disease and to compare with anatomic location of white matter tracts.
Methods:
Forty-six patients with Wilson disease were examined. Axial T1-weighted inversion-recovery, axial T2-weighted spin-echo, and coronal T2*-weighted gradient-echo MR images were performed. Imaging studies were compared with clinical data.
Results:
Seventeen patients showed abnormalities in the region coinciding with the following white matter tracts: corticospinal tract (24%, n = 11), dentatorubrothalamic tract (24%, n = 11), and pontocerebellar tract (17%, n = 8).
Conclusion:
Abnormal extrapyramidal and pyramidal white matter tracts are part of the neuroimaging spectrum of Wilson disease. No significant correlation was found with neurologic groups and individual white matter tracts affected.