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Vitamin E in intestinal fat malabsorption

V S Ghalaut1, P S Ghalaut, S Kharb

  • 1Department of Biochemistry and Medicine, Pt. Bhagwat Dayal Sharma Post-Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

Annals of Nutrition & Metabolism
|January 1, 1995
PubMed
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Tropical sprue patients with low vitamin E showed impaired immune function and neuropathy. Vitamin repletion improved T-cell functions and neuropathy symptoms.

Area of Science:

  • Immunology
  • Nutritional Science
  • Neurology

Background:

  • Tropical sprue is a malabsorptive condition with chronic duration.
  • Patients often present with nutrient deficiencies and immune dysregulation.
  • Neurological complications like polyneuropathy can occur in tropical sprue.

Purpose of the Study:

  • To investigate the role of vitamin E in tropical sprue.
  • To assess immune function in patients with tropical sprue.
  • To evaluate the impact of vitamin E repletion on immune function and neuropathy.

Main Methods:

  • Study included 5 patients with tropical sprue (8-10 years).
  • Assessed serum vitamin E levels.
  • Evaluated cell-mediated immunity using 2,4-dinitrochlorobenzene (DNCB) skin test.

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  • Monitored for polyneuropathy.

    • Main Results:

    • Significantly low serum vitamin E levels were observed in all patients.
    • Cell-mediated immune mechanisms were depressed.
    • Polyneuropathy was a common finding.
    • Vitamin E repletion led to significant improvement in T-cell functions.
    • Neuropathy symptoms also markedly improved following vitamin E repletion.

    Conclusions:

    • Vitamin E deficiency is linked to immune dysfunction in tropical sprue.
    • Vitamin E repletion can restore T-cell functions.
    • Supplementation may alleviate neurological complications in tropical sprue.