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Related Experiment Videos

Increased peak flow variability in children with asymptomatic hyperresponsiveness

P G Gibson1, S Mattoli, M R Sears

  • 1Dept of Medicine, St Joseph's Hospital, Hamilton, Ontario, Canada.

The European Respiratory Journal
|October 1, 1995
PubMed
Summary
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Asymptomatic children with methacholine airway hyperresponsiveness show increased diurnal peak expiratory flow (PEF) variability, similar to asthmatic children. This suggests mild airflow obstruction even without asthma symptoms.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Allergy and Immunology

Background:

  • Increased methacholine airway responsiveness is detected in children without current or past asthma symptoms.
  • The clinical significance of this airway hyperresponsiveness in asymptomatic children remains unclear.
  • Investigating associated airflow obstruction markers like peak expiratory flow (PEF) variability is crucial.

Purpose of the Study:

  • To determine if airway hyperresponsiveness in asymptomatic children is associated with abnormal peak expiratory flow (PEF) variability.
  • To compare PEF diurnal variation in asymptomatic hyperresponsive children with symptomatic asthmatic children and normal controls.
  • To assess the perception of airway constriction in these groups.

Main Methods:

Related Experiment Videos

  • Studied 12 asymptomatic children with methacholine hyperresponsiveness, 12 symptomatic asthmatic children, and 12 normal children (aged 9-14).
  • Examined diurnal variation of peak expiratory flow (PEF) and response to inhaled bronchodilator in all groups.
  • Assessed perception of methacholine-induced airway constriction.

    • Main Results:

    • Asymptomatic hyperresponsive children exhibited increased diurnal PEF variation (9.3%), comparable to symptomatic asthmatics (10.7%) and greater than normal children (5.7%).
    • Methacholine-induced airway constriction was perceived as symptoms in subjects from all groups.
    • This indicates asymptomatic hyperresponsive children experience mild variable airflow obstruction.

    Conclusions:

    • Asymptomatic children with methacholine airway hyperresponsiveness demonstrate evidence of mild variable airflow obstruction.
    • Increased diurnal PEF variability in these children suggests subclinical airway dysfunction.
    • Lack of symptoms may relate to insufficient stimulus or absence of eosinophilic airway inflammation.