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Hyperbaric oxygenation therapy for cyclophosphamide-induced haemorrhagic cystitis
H Yazawa1, T Nakada, I Sasagawa
1Department of Urology, Yamagata University School of Medicine, Japan.
International Urology and Nephrology
|January 1, 1995
Summary
Hyperbaric oxygen therapy (HBO) effectively treated hemorrhagic cystitis in a patient undergoing chemotherapy. This innovative treatment resolved hematuria and improved bladder healing without side effects.
Area of Science:
- Oncology
- Urology
- Hyperbaric Medicine
Background:
- Cyclophosphamide is a common chemotherapy agent used for ovarian tumors.
- Chemotherapy can induce hemorrhagic cystitis, a serious bladder complication.
- Hyperbaric oxygenation (HBO) is a therapeutic technique involving 100% oxygen at increased atmospheric pressure.
Observation:
- A 41-year-old female patient developed hemorrhagic cystitis during cyclophosphamide therapy.
- The patient received daily HBO treatments (100% oxygen, 2 ATA, 60 minutes for 30 days).
Findings:
- Following HBO therapy, the patient's hemorrhagic cystitis symptoms subsided.
- Hematuria resolved, and cystoscopic examination showed significant improvement in bladder condition.
- No adverse side effects were reported during the HBO treatment course.
Implications:
- HBO therapy demonstrates a beneficial effect in managing cyclophosphamide-induced hemorrhagic cystitis.
- This suggests HBO as a potential supportive treatment for chemotherapy-related bladder toxicity.
- Further research into HBO's role in oncological supportive care is warranted.