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Decrease of interferon-induced 2',5'-oligoadenylate synthetase activity in cirrhotic rat liver

I Miyajima1, M Sata, Y Uchimura

  • 1Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|December 1, 1995
PubMed
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Hepatic fibrosis, induced by thioacetamide in rats, significantly reduced liver 2

Area of Science:

  • Hepatology
  • Immunology
  • Biochemistry

Background:

  • Interferon (IFN) therapy is crucial for treating viral hepatitis.
  • Hepatic fibrosis can alter liver function and drug responses.
  • 2',5'-oligoadenylate synthetase (2-5AS) is an enzyme induced by IFN.

Purpose of the Study:

  • To investigate how hepatic fibrosis affects interferon-induced 2',5'-oligoadenylate synthetase (2-5AS) activity in a rat model.
  • To determine if liver cirrhosis attenuates the hepatic response to interferon.

Main Methods:

  • A rat model of liver cirrhosis was established using thioacetamide.
  • Serum and liver homogenate 2-5AS activity were measured after murine interferon administration.
  • Statistical analysis was performed to compare control and cirrhotic groups.

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Main Results:

  • No significant difference in serum 2-5AS activity was observed between control and cirrhotic rats.
  • Liver homogenate 2-5AS activity was significantly lower in cirrhotic rats compared to controls (171 +/- 10.2 vs. 105 +/- 18.5 pmol/micrograms, p < 0.01).

Conclusions:

  • Hepatic fibrosis attenuates the effect of interferon in the liver.
  • Decreased induction of hepatic 2-5AS activity is a potential mechanism for this attenuation in cirrhotic livers.