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Germanium intoxication with sensory ataxia

T Asaka1, E Nitta, T Makifuchi

  • 1Department of Neurology, Kanazawa University School of Medicine, Japan.

Journal of the Neurological Sciences
|June 1, 1995
PubMed
Summary

Sensory ataxia is a rare complication of inorganic germanium intoxication. Chronic, high-dose exposure can lead to irreversible neurological and renal damage, as seen in this case.

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Area of Science:

  • Neurology
  • Toxicology
  • Nephrology

Background:

  • Inorganic germanium (Ge) is a metalloid used in dietary supplements, with potential for toxicity.
  • Germanium intoxication is uncommon, and sensory ataxia is a rare reported manifestation.

Observation:

  • A 63-year-old woman developed sensory ataxia, peripheral neuropathy, and renal dysfunction after 6 years of inorganic germanium supplementation (36 mg/day).
  • Elevated germanium levels were detected in her hair and nails, confirming intoxication.
  • Neurological and renal damage persisted after cessation of germanium intake.

Findings:

  • Autopsy revealed degeneration of dorsal root ganglion cells and the spinal cord's dorsal columns, consistent with sensory pathway damage.
  • The patient succumbed to pneumonia and sepsis, complications likely exacerbated by her underlying condition.

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  • This case, along with two prior reports, suggests a link between chronic, high-dose inorganic germanium exposure and sensory ataxia.

    • Implications:

    • Highlights the potential neurotoxicity and nephrotoxicity of inorganic germanium, even at doses previously considered safe.
    • Emphasizes the importance of monitoring patients on long-term germanium supplements for signs of toxicity.
    • Suggests that sensory ataxia may be a dose-dependent, chronic toxicity effect of inorganic germanium.