Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoreactive prostate-specific antigen in lung tumors

M Levesque1, H Yu, M D'Costa

  • 1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Journal of Clinical Laboratory Analysis
|January 1, 1995
PubMed
Summary

Prostate-specific antigen (PSA) was detected in lung tumors for the first time. This finding suggests PSA may be a ubiquitous marker of steroid hormone action across various cancer types.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electronic field effect detection of SARS-CoV-2 N-protein before the onset of symptoms.

Biosensors & bioelectronics·2022
Same author

A multi-cancer detection test: focus on the positive predictive value.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer.

British journal of cancer·2015
Same author

Clinical utility of kallikrein-related peptidases (KLK) in urogenital malignancies.

Thrombosis and haemostasis·2013
Same author

Folate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients.

Clinical biochemistry·2013
Same author

CUB and zona pellucida-like domain-containing protein 1 (CUZD1): a novel serological biomarker for ovarian cancer.

Clinical biochemistry·2012

Area of Science:

  • Oncology
  • Biochemistry

Background:

  • Prostate-specific antigen (PSA) is a known biomarker for prostate cancer.
  • Previous research indicated PSA presence in breast and other tumors, potentially as a favorable prognostic indicator.

Purpose of the Study:

  • To investigate the presence and characteristics of PSA in lung tumors.
  • To explore the association of PSA with specific lung cancer subtypes and patient demographics.

Main Methods:

  • Utilized a sensitive assay to detect PSA in lung adenocarcinoma and squamous cell carcinoma tissue extracts.
  • Quantified PSA levels and characterized its molecular form (33 KDa free PSA).

Main Results:

  • PSA was detected in lung adenocarcinomas and squamous cell carcinomas.

Related Experiment Videos

  • PSA levels were measurable by commercial assays and primarily found as 33 KDa free PSA.
  • PSA presence correlated with male patients and adenocarcinoma subtype.

    • Conclusions:

    • PSA is present in lung tumors, indicating its potential as a ubiquitous biochemical marker.
    • The physiological role and prognostic significance of PSA in lung cancer require further investigation.