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Related Experiment Videos

Malignant joint effusions secondary to solid tumor metastasis

R K Munn1, S T Pierce, D Sloan

  • 1Department of Internal Medicine, University of Kentucky, Lexington, USA.

The Journal of Rheumatology
|May 1, 1995
PubMed
Summary

Malignant knee effusions from solid tumors are rare, with the knee being the most common site. Diagnosis requires high clinical suspicion, confirmed by synovial fluid cytology or biopsy.

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Area of Science:

  • Oncology
  • Rheumatology
  • Pathology

Background:

  • Malignant joint effusions secondary to solid tumors are uncommon.
  • Literature review and case report of breast cancer with bilateral malignant knee effusions.

Observation:

  • The knee is the predominant site for malignant joint effusions.
  • Effusions are often non-inflammatory and bloody.
  • Synovial fluid cytology and biopsy can aid diagnosis.

Findings:

  • 27 cases of malignant joint effusions from solid tumors reported, including this case.
  • Synovial biopsy positive in 11/16 cases.
  • Synovial fluid cytology positive in 50% of cases.

Implications:

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  • Metastatic arthritis indicates a poor prognosis.
  • Early diagnosis is crucial for patient management.
  • High clinical suspicion is essential for timely diagnosis and treatment.