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[Trace elements in long-term total parenteral nutrition]

Y Itokawa1

  • 1Graduate School of Medicine, Kyoto University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 1, 1996
PubMed
Summary

Long-term total parenteral nutrition (TPN) can lead to trace element deficiencies, including zinc, copper, and chromium. Supplementation is crucial for preventing serious health issues in TPN patients.

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Area of Science:

  • Clinical Nutrition
  • Trace Element Metabolism
  • Parenteral Nutrition

Context:

  • Patients undergoing long-term total parenteral nutrition (TPN) are at risk of developing deficiencies in essential trace elements.
  • These deficiencies can manifest with distinct clinical symptoms and biochemical abnormalities.

Purpose:

  • To outline the deficiency symptoms associated with various trace elements (zinc, copper, manganese, selenium, chromium, molybdenum) in patients receiving TPN.
  • To provide estimated daily requirements of these trace elements for adult TPN patients.

Summary:

  • Zinc deficiency presents as dermatitis and alopecia; copper deficiency causes anemia and neutropenia; manganese deficiency is linked to bone changes.
  • Selenium deficiency can lead to cardiomyopathy, chromium deficiency results in neuropathy and glucose intolerance, and molybdenum deficiency causes amino acid intolerance.
  • Recommended daily TPN intakes include: zinc (3-4 mg), copper (0.02-0.05 mg), iron (1-2 mg), manganese (0.15-0.80 mg), selenium (0.02-0.05 mg), chromium (0.01-0.015 mg), molybdenum (0.075-0.250 mg), and iodine (0.070-0.140 mg).

Impact:

  • Highlights the critical need for monitoring and supplementing trace elements in TPN regimens.
  • Informing clinical practice to prevent and manage TPN-induced trace element deficiencies.
  • Establishes recommended daily allowances for trace elements in parenteral nutrition for adults.

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