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Related Experiment Videos

[Problems related to trace element determination in biological materials]

K Okamoto1

  • 1Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Tokushima.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 1, 1996
PubMed
Summary

Accurate ultratrace element analysis in biological samples requires strict contamination control and appropriate methods. Developing human serum reference materials is crucial for reliable analytical quality assurance.

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Area of Science:

  • Analytical Chemistry
  • Environmental Science
  • Biochemistry

Context:

  • Determining ultratrace elements (Cr, Cd, Co, Ni, V) in biological matrices presents significant analytical challenges.
  • Contamination from devices, reagents, and the environment is a critical hurdle in ultratrace analysis.
  • Specific challenges include avoiding contamination (e.g., stainless steel needles for Cr in serum) and ensuring labware/reagent purity.

Purpose:

  • To describe analytical problems in ultratrace element determination in biological materials.
  • To highlight the importance of contamination prevention and appropriate analytical techniques.
  • To emphasize the need for certified reference materials for quality assurance.

Summary:

  • This study addresses ultratrace element analysis in biological samples, focusing on contamination control and method selection.

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  • Key techniques discussed include graphite furnace atomic absorption spectrometry (GFAAS) with background correction and matrix modifiers, and ICP mass spectrometry (ICP-MS) addressing polyatomic ion interferences.
  • The critical role of biological certified reference materials (CRMs) is emphasized, alongside the limited availability of human serum CRMs.

    • Impact:

    • Provides guidance on overcoming contamination and interference issues in ultratrace element analysis.
    • Underscores the necessity of rigorous quality control measures in biological sample analysis.
    • Highlights the urgent need for developing representative human serum and urine reference materials for improved analytical accuracy and reliability.