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[Essential trace elements and immunity]

H Kodama1

  • 1Department of Pediatrics, Teikyo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 1, 1996
PubMed
Summary

Essential trace elements like zinc, iron, copper, and selenium are vital for a healthy immune system. Deficiencies impair cell-mediated immunity, but proper supplementation and balance are key to maintaining immune function.

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Area of Science:

  • Trace Element Metabolism
  • Immunology
  • Human Nutrition

Context:

  • The immune system relies on various micronutrients for optimal function.
  • Essential trace elements, including zinc, iron, copper, and selenium, play critical roles in immune cell development and activity.
  • Understanding the impact of these elements is crucial for maintaining immunocompetence.

Purpose:

  • To review the multifaceted effects of zinc, iron, copper, and selenium on the human immune system.
  • To elucidate the specific roles of these trace elements in immune cell function, particularly cell-mediated immunity.
  • To highlight the consequences of both deficiency and excess of these essential nutrients on immune status.

Summary:

  • Zinc, iron, copper, and selenium are indispensable for immune system integrity and function.
  • Deficiencies primarily affect cell-mediated immunity, with minimal impact on B cell function.
  • Supplementation can correct immunological abnormalities, but excessive intake can be detrimental, emphasizing the need for balance.

Impact:

  • Provides critical insights into the nutritional requirements for a robust immune response.
  • Informs strategies for managing immune dysfunction related to trace element status.
  • Underscores the importance of maintaining optimal levels of essential trace elements for overall health and immunocompetence.

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