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[Overview--suppression effect of essential trace elements on arteriosclerotic development and it's mechanism]
Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 1, 1996
Summary
Low selenium and magnesium levels, and a high calcium-to-magnesium ratio, are linked to accelerated arteriosclerosis and vascular lesions in stroke-prone spontaneously hypertensive rats (SHRSP). These mineral imbalances may contribute to cardiovascular disease development.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Nutritional Science
Context:
- Oxidized low-density lipoprotein (LDL) is a known trigger for arteriosclerosis.
- Mineral imbalances, including decreased selenium and magnesium, are observed in conditions associated with vascular damage.
Purpose:
- To investigate the role of selenium and magnesium imbalances in the development of arteriosclerosis and vascular lesions.
- To compare mineral levels and ratios in stroke-prone spontaneously hypertensive rats (SHRSP) with normotensive controls.
Summary:
- Selenium and magnesium levels were decreased in serum and organs of SHRSP rats.
- Elevated calcium-to-magnesium ratios were found in SHRSP rats compared to Wistar Kyoto rats (WKY).
- These mineral changes correlate with accelerated vascular lesions in SHRSP, suggesting a link to arteriosclerosis development.
Impact:
- Highlights the potential contribution of specific mineral deficiencies and imbalances to the pathogenesis of arteriosclerosis.
- Suggests that monitoring and correcting selenium and magnesium levels could be a therapeutic strategy for preventing vascular lesions.
- Provides insights into the biochemical mechanisms underlying hypertension-related vascular disease.