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[Liver diseases and essential trace elements]

K Suzuki1, R Oyama, E Hayashi

  • 1Department of Internal Medicine, Surugadai Nihon University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 1, 1996
PubMed
Summary

Trace element levels change in various liver diseases. Copper increases in cirrhosis and cancer, while other minerals like calcium and zinc decrease, indicating liver dysfunction.

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Hepatology

Context:

  • Trace elements are essential components of metalloproteins and metalloenzymes.
  • Copper plays a role in preventing hepatic fibrosis by aiding collagen biosynthesis.
  • Altered trace element profiles are observed across different stages of liver disease.

Purpose:

  • To investigate the changes in serum concentrations of various trace elements in patients with different liver conditions.
  • To correlate these trace element abnormalities with pathological states like liver dysfunction, cholestasis, fibrosis, and regeneration.

Summary:

  • Serum concentrations of calcium, magnesium, phosphorus, and zinc decrease as liver disease progresses from chronic hepatitis to cirrhosis.
  • In contrast, copper concentration increases in liver cirrhosis and hepatocellular carcinoma.
  • Acute hepatitis shows decreased calcium, magnesium, and zinc, with decreased phosphorus, iron, and copper.

Impact:

  • Abnormal trace element levels can serve as indicators of liver dysfunction, cholestasis, hepatic fibrosis, and regeneration.
  • Understanding these biochemical alterations can aid in diagnosing and managing liver diseases.
  • Highlights the critical role of trace elements in liver health and disease pathogenesis.

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