Effect of "core" 2'5'-oligoadenylates on the phosphorylation-dependent calcium channels in GH3 cells

The effect of intracellular application of isolated and purified forms of "core" oligoadenylates (2',5',ApApA, 2',5'ApApepoxyA and 3',5'ApApA) on the phosphorylation-dependent calcium channels in GH3 cells was investigated. The role of Mg2+ ions in realizing of the processes of enhancement of phosphorylation-dependent calcium currents and prolongation of their wash-out during whole-cell patch-clamp experiments was examined.