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Experimental study on the kinetics of mucociliary activity in rabbit airways
1Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Physiologica Hungarica
|January 1, 1995
Abstract:
Noninvasive radioaerosol technique was applied to investigate the mucociliary activity of bronchial mucosa using 99mTc-labelled homologous erythrocytes for inhalation. Radioactivity was continuously measured for 60 min with a gamma camera connected online to the computer. Time-activity kinetic parameters were calculated by a monoexponential model. Test substance azelastine and bromhexine were used to demonstrate the validity of experimental method discussed.