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Molecular mechanisms of endotoxin activity
J Schletter1, H Heine, A J Ulmer
1Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Parkallee 22, D-23845 Borstel, Germany.
Archives of Microbiology
|December 1, 1995
Abstract:
Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.