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Neuropsychopathological changes by organophosphorus compounds--a review
1Walther-Straub-Institut für Pharmakologie und Toxikologie, Universität München, Germany.
Human & Experimental Toxicology
|November 1, 1995
Summary
Organophosphate insecticide exposure can cause neurological issues like intermediate syndrome and organophosphate-induced delayed neuropathy (OPIDN). Asymptomatic exposure does not appear to increase the risk of long-term neuropsychological effects.
Area of Science:
- Neuroscience
- Toxicology
- Environmental Health
Background:
- Organophosphate insecticides are widely used, posing potential risks to human health.
- Neuropsychological effects following organophosphate exposure are a significant concern.
Purpose of the Study:
- To review the available literature on neuropsychopathological changes after organophosphate insecticide exposure.
- To delineate the types and risks of neurological sequelae associated with organophosphate intoxication.
Main Methods:
- Literature review of studies on organophosphate exposure and neuropsychological outcomes.
- Analysis of documented neurological syndromes and long-term effects.
Main Results:
- Subacute effects include intermediate syndrome (myopathy) and organophosphate-induced delayed neuropathy (OPIDN).
- Long-term behavioral, mental, and visual impairments can occur after high-dose, repeated exposures.
- Asymptomatic exposure is not linked to increased risk of delayed or permanent neuropsychological damage.
Conclusions:
- Organophosphate exposure can lead to distinct neurological syndromes.
- The risk of severe neuropsychological effects is primarily associated with acute, high-dose, or repeated intoxications.
- Current data suggest asymptomatic exposure does not elevate the risk of lasting neurological harm.