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Paclitaxel/cisplatin in advanced non-small-cell lung cancer (NSCLC)
R Pirker1, G Krajnik, S Zöchbauer
1Department of Oncology, University of Vienna Medical School, Austria.
Background:
Paclitaxel (Taxol) as single agent has shown promising activity in advanced non-small-cell lung cancer (NSCLC). Because paclitaxel lends itself to combination with other anticancer drugs, we have determined the efficacy of paclitaxel combined with cisplatin in patients with advanced NSCLC in a phase II trial.
Patients And Methods:
Twenty patients with NSCLC stage IIIB or IV were treated with paclitaxel (175 mg/m2) as a 3-hour infusion after standard premedication on day 1 and cisplatin (50 mg/m2 daily) on days 1 and 2. Treatment was repeated every 3 weeks.
Results:
All 20 patients were evaluable for response and toxic effects. Partial responses were seen in 7 (35%) patients and no change in 9 (45%) patients. Major side effects included leukopenia, anemia, alopecia and dose-limiting neurotoxicity.
Conclusions:
Paclitaxel/cisplatin has shown good antitumor activity in patients with advanced NSCLC and should be further evaluated in this disease. Because neurotoxicity has been dose-limiting, methods for its prevention or early detection should further enhance the clinical value of this combination chemotherapy.