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Artificial liver. Evolution and future perspectives

J Rozga1, A A Demetriou

  • 1Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 1, 1995
PubMed
Summary
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Liver transplantation is limited, driving research into alternative liver support systems. Recent advances in technology have led to a new generation of liver assist devices currently in clinical trials.

Area of Science:

  • Hepatology
  • Biomedical Engineering
  • Transplantation Medicine

Background:

  • Whole organ transplantation is the primary treatment for liver failure but faces limitations like donor shortage and high costs.
  • Alternative liver support systems have been explored since the 1950s to address these limitations.

Purpose of the Study:

  • To review the historical development of liver support systems.
  • To critically evaluate the current status of liver assist devices.
  • To project future directions in the field of liver support systems.

Main Methods:

  • Review of past experiences with liver support systems.
  • Critical examination of current liver assist device technology.
  • Analysis of recent advancements in hepatocyte culture, biomaterials, and membrane technology.

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Main Results:

  • Early liver support systems showed limited success.
  • Recent technological advancements have enabled a new generation of liver assist devices.
  • Several novel devices are currently undergoing clinical evaluation.

Conclusions:

  • Liver assist devices offer a promising alternative to whole organ transplantation.
  • Continued innovation in biomaterials, hepatocyte technology, and device engineering is crucial.
  • The future of liver support systems lies in advanced extracorporeal devices and bio-hybrid artificial livers.