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Antihistone antibodies in scleroderma
A Parodi1, M Drosera, L Barbieri
1Department of Dermatology, University of Genoa, Italy.
Background:
Antihistone antibodies (AHA) are usually considered the serological marker of drug-induced lupus erythematosus, but recently they have been found in patients with systemic scleroderma (SSc) and morphea.
Objective And Methods:
We determined AHA in 43 patients with SSc, 4 patients with overlap syndrome and 11 with morphea.
Results And Conclusions:
AHA were demonstrated in 41.8% of the SSc patients and in 36.3% of the morphea patients. Only 1 patient with overlap syndrome had AHA. Our SSc patients with AHA had frequent cardiac and renal involvements suggesting a prognostic value of AHA. In our morphea patients AHA did not correlate with clinical features.