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Purely cutaneous Rosai-Dorfman disease
M Skiljo1, E García-Lora, J Tercedor
1Department of Dermatology, Hospital Virgen de las Nieves, Granada, Spain.
Dermatology (Basel, Switzerland)
|January 1, 1995
Abstract:
Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.