Human skeletal muscle mitochondria in aging: lack of detectable morphological and enzymic defects

¹Istituto di Morfologia Umana Normale, Università di Ancona.

Biochemistry and Molecular Biology International

|November 1, 1995

Abstract:

We have investigated structural and functional properties of skeletal muscle mitochondria obtained from biopsies from young and old individuals. The morphometric analysis of muscle sections revealed a tendency to an increase of total area, numerical density and volume density of mitochondria in the aged. The enzymatic activities of NADH-Coenzyme Q reductase, succinate cytochrome c reductase, ubiquinol-cytochrome c reductase exhibited a high variability of specific activities without any correlation with age. Expression of the values as enzyme turnovers reduced the variability but was unable to reveal any age-dependent modification.

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Abstract:

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