Feasibility of glucagon eyedrops for clinical use in hypoglycemia

Although sufficient amount of glucagon can be taken up into systemic circulation through ocular route, the concentration of eyedrops needed at 7.5% would be too high and the price of the doses would be too expensive to be desirable. Attempts have been made to reduce the doses of glucagon needed for systemic delivery through ocular route by adding absorption enhancers such as 0.5% BL-9 or 0.5% Brij-78. With these absorption enhancers, the effective concentrations of glucagon eyedrops can be lowered to 0.05% in rabbit eyes and could be lowered to 1.25% in human eyes which would be reasonable to be used in the clinics.