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Related Experiment Videos

Visual function in recovered ethambutol optic neuropathy

L C Woung1, J R Jou, S L Liaw

  • 1Department of Ophthalmology, National Taiwan University School of Medicine, Taipei, Republic of China.

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
|January 1, 1995
PubMed
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Ethambutol optic neuropathy can impair vision, but visual acuity often recovers. However, other visual functions like color vision and contrast sensitivity may remain incomplete after treatment.

Area of Science:

  • Ophthalmology
  • Neuro-ophthalmology
  • Optic Neuropathy

Background:

  • Ethambutol is a common antibiotic used to treat tuberculosis.
  • Ethambutol optic neuropathy is a known side effect that can cause vision loss.
  • Visual acuity recovery is expected, but the extent of recovery in other visual functions is less understood.

Purpose of the Study:

  • To investigate the recovery of visual functions beyond visual acuity in patients with ethambutol optic neuropathy.
  • To quantify the extent and patterns of visual deficits after discontinuing ethambutol.

Main Methods:

  • A cohort of 36 patients with ethambutol optic neuropathy was studied.
  • Patients underwent comprehensive visual function testing including visual evoked potentials (VEPs), color vision tests, critical flicker frequency (CFF), visual field perimetry, contrast sensitivity, and pupil cycle time.

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Main Results:

  • While visual acuity improved in 15 patients, other functions showed persistent deficits.
  • Delayed VEP latency (34.5%), color vision defects (48.3%), abnormal red CFF (51.7%), visual field defects (58.6%), reduced contrast sensitivity (62.1%), and prolonged pupil cycle time (72.4%) were observed.
  • The order of functional recovery was visual acuity > VEPs > color sense > CFF > visual field > contrast sensitivity > pupil cycle time.

Conclusions:

  • Recovery of visual functions after ethambutol optic neuropathy is often incomplete.
  • Persistent deficits in color vision, contrast sensitivity, and visual fields are common despite visual acuity improvement.
  • Long-term monitoring of visual function is recommended for patients treated with ethambutol.