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Modification by analgesics of the susceptibility to antibiotics in Serratia marcescens
1Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Barcelona, Spain.
Abstract:
The influence of analgesics at low concentrations on permeability and beta-lactamase expression have been studied "in vitro". The effect of these drugs on major outer membrane proteins and the lipopolysaccharide was evaluated. Acetylsalicylate and paracetamol induced modifications in susceptibility to a large variety of antibiotics when tested at therapeutic concentrations. The results suggested that when analgesics and antibiotics are administered simultaneously, the interaction between both kinds of drugs can alter the response of microorganisms to antibiotics.
Insights
Low concentrations of common analgesics like acetylsalicylate and paracetamol can alter bacterial susceptibility to antibiotics. Simultaneous administration may change how microorganisms respond to antibiotic treatments.
Area of Science:
- Microbiology
- Pharmacology
- Antimicrobial Resistance
Background:
- The widespread use of analgesics necessitates understanding their potential impact on microbial physiology.
- Beta-lactamase expression and outer membrane permeability are key factors in bacterial antibiotic resistance.
Purpose of the Study:
- To investigate the in vitro effects of analgesics at low concentrations on bacterial permeability and beta-lactamase expression.
- To evaluate how analgesics affect major outer membrane proteins and lipopolysaccharides.
Main Methods:
- In vitro study of analgesic influence on bacterial permeability.
- Assessment of beta-lactamase expression in response to drug exposure.
- Analysis of outer membrane protein and lipopolysaccharide modifications.
Main Results:
- Acetylsalicylate and paracetamol induced significant modifications in bacterial susceptibility to various antibiotics at therapeutic concentrations.
- Observed alterations in outer membrane proteins and lipopolysaccharide structure.
- Demonstrated changes in beta-lactamase expression and permeability.
Conclusions:
- Analgesics, even at low concentrations, can modulate bacterial antibiotic susceptibility.
- Concurrent administration of analgesics and antibiotics can lead to altered antimicrobial treatment outcomes.
- Further research is warranted to explore drug-drug interactions in clinical settings.