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Acute monoblastic leukaemia with conjunctival tumours
1Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|January 1, 1995
Summary
Bilateral conjunctival tumors signaled a relapse of acute monoblastic leukemia in a young woman. Treatment with combined chemotherapy achieved complete remission of leukemia in the conjunctiva, bone marrow, and skin.
Area of Science:
- Hematology
- Ophthalmology
- Oncology
Background:
- Acute monoblastic leukemia (AML) is a rare hematologic malignancy.
- Relapse of AML can manifest in various tissues.
- Conjunctival involvement in AML relapse is exceptionally uncommon.
Observation:
- A 25-year-old woman presented with bilateral conjunctival tumors.
- These tumors were the initial clinical sign of acute monoblastic leukemia relapse.
- Ocular findings included pink, raised lesions without pain or visual disturbance.
Findings:
- Biopsy confirmed dense mononuclear cell infiltration consistent with leukemia.
- Bone marrow and skin infiltration were also present.
- No central nervous system involvement was detected.
Implications:
- Conjunctival tumors can be an early indicator of AML relapse.
- Prompt diagnosis and treatment are crucial for managing extramedullary relapse.
- Systemic and intrathecal chemotherapy can induce remission in such cases.