Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Self-complementary oligopeptide matrices support mammalian cell attachment

S Zhang1, T C Holmes, C M DiPersio

  • 1Department of Biology 68-233, Massachusetts Institute of Technology, Cambridge 02139-4307, USA.

Biomaterials
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Access to and quality of care for sexual and gender minority women living with HIV in Metro Vancouver, Canada: Results from a longitudinal cohort study.

Women's health (London, England)·2023
Same author

Human papillomavirus and oral and oropharyngeal carcinoma: the essentials.

Australian dental journal·2018
Same author

Reasons of repeat dental treatment under general anaesthesia: A retrospective study.

European journal of paediatric dentistry·2018
Same author

A clinical trial of a novel emulsion for potential use as a saliva substitute in patients with radiation-induced xerostomia.

Journal of oral rehabilitation·2017
Same author

Does age matter? Sexual event-level analysis of age-disparate sexual partners among gay, bisexual and other men who have sex with men (GBM) in Vancouver, Canada.

Sexually transmitted infections·2016
Same author

Awareness and use of nonoccupational post-exposure prophylaxis among men who have sex with men in Vancouver, Canada.

HIV medicine·2016
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
Same journal

Peptide coacervate-mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy.

Biomaterials·2026
See all related articles

Ionic self-complementary oligopeptides like RAD16 and EAK16 form stable, porous membranous matrices in physiological solutions. These peptide matrices support mammalian cell attachment, showing potential for tissue regeneration and healing applications.

Area of Science:

  • Biomaterials Science
  • Peptide Chemistry
  • Cell Biology

Background:

  • Ionic self-complementary oligopeptides represent a novel class of self-assembling molecules.
  • RAD16 and EAK16 are specific examples of these oligopeptides, characterized by alternating ionic hydrophilic and hydrophobic amino acid sequences.

Purpose of the Study:

  • To describe a new class of ionic self-complementary oligopeptides.
  • To investigate the self-assembly properties of these oligopeptides into macroscopic structures.
  • To evaluate the potential of these structures as substrates for mammalian cell attachment.

Main Methods:

  • Synthesis and characterization of ionic self-complementary oligopeptides (RAD16, EAK16).
  • Induction of self-assembly into membranous matrices using physiological solutions and buffers.

Related Experiment Videos

  • Assessment of matrix morphology (ordered filaments, porous enclosures).
  • In vitro cell attachment assays using various mammalian cell types.

    • Main Results:

    • Oligopeptides spontaneously assemble into stable, macroscopic membranous matrices.
    • Matrices exhibit ordered filamentous structures with porous enclosures.
    • Mammalian cells successfully attach to both RAD16 and EAK16 matrices.

    Conclusions:

    • Ionic self-complementary oligopeptides form versatile, cell-adhesive biomaterial matrices.
    • These peptide matrices offer a novel system for studying in vitro cell attachment mechanisms.
    • Potential applications include tissue regeneration, transplantation, and wound healing.