Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Heparinization for routine hemodialysis

¹Department of Medicine, School of Medicine, University of Louisville, KY 40292, USA.

Advances in Renal Replacement Therapy

|October 1, 1995

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pathogens of Anoplura and Mallophaga (lice).

Bulletin of the World Health Organization·2010

Same author

Water processing for hemodialysis. Part I: a historical perspective.

Seminars in dialysis·2009

Same author

Resistance to intercompartmental mass transfer limits beta2-microglobulin removal by post-dilution hemodiafiltration.

Kidney international·2006

Same author

What clinically important advances in understanding and improving dialyzer function have occurred recently?

Seminars in dialysis·2001

Same author

Increasing dialysate flow rate increases dialyzer urea mass transfer-area coefficients during clinical use.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2001

Same author

Ultrapure dialysate: a desirable and achievable goal for routine hemodialysis.

Seminars in dialysis·2000

Same journal

Needed: a catalyst for change.

Advances in renal replacement therapy·2004

Same journal

Racial and ethnic differences in the incidence and progression of focal segmental glomerulosclerosis in children.

Advances in renal replacement therapy·2004

Same journal

Incorporating ethnic and cultural food preferences in the renal diet.

Advances in renal replacement therapy·2004

Same journal

Literature review and implications for social work practice with Hispanic dialysis patients.

Advances in renal replacement therapy·2004

Same journal

Diversity and patient care in a shrinking world.

Advances in renal replacement therapy·2004

Same journal

Genetic variation in the epithelial sodium channel: a risk factor for hypertension in people of African origin.

Advances in renal replacement therapy·2004

See all related articles

Achieving optimal anticoagulation during hemodialysis with heparin requires individualized dosing. Pharmacodynamic modeling or empirical methods can determine appropriate heparin doses, minimizing risks associated with clotting and bleeding.

Area of Science:

Nephrology
Pharmacology
Biomedical Engineering

Background:

Hemodialysis necessitates anticoagulation with heparin to prevent extracorporeal circuit clotting.
Activated whole blood clotting times (aWBCT) monitor anticoagulation levels during dialysis.
Heparin's anticoagulant effect varies with the test used, requiring unit-specific target ranges.

Purpose of the Study:

To review optimal heparin anticoagulation strategies for hemodialysis.
To discuss methods for individualizing heparin dosage.
To identify factors contributing to suboptimal anticoagulation outcomes.

Main Methods:

Review of heparin anticoagulation principles in hemodialysis.
Discussion of pharmacokinetic and pharmacodynamic considerations.

Related Experiment Videos

Analysis of factors influencing anticoagulation efficacy and adverse events.

Main Results:

Continuous heparin infusion following a loading dose is preferred over intermittent boluses.
Individualized heparin dosing, determined by pharmacodynamic models or empirical trials, is crucial.
Adverse outcomes are often linked to technical issues rather than patient-specific factors.

Conclusions:

Individualized heparin dosing is essential for safe and effective hemodialysis anticoagulation.
Pharmacodynamic modeling offers a systematic approach to dose determination.
Attention to technical aspects of dialysis and heparin administration is critical for preventing complications.