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Related Experiment Videos

Decrease in intra-abdominal visceral fat may reduce blood pressure in obese hypertensive women

H Kanai1, K Tokunaga, S Fujioka

  • 1Division of Internal Medicine, Toyonaka Municipal Hospital, Osaka, Japan.

Hypertension (Dallas, Tex. : 1979)
|January 1, 1996
PubMed
Summary

A 12-week low-calorie diet significantly reduced blood pressure in obese women by decreasing intra-abdominal visceral fat, not just overall body weight. This reduction in visceral fat may improve glucose tolerance, aiding blood pressure management.

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Area of Science:

  • Endocrinology
  • Cardiovascular Health
  • Metabolic Syndrome

Background:

  • Obesity is a major risk factor for hypertension.
  • Abdominal fat distribution, particularly visceral fat, is strongly linked to metabolic and cardiovascular diseases.
  • Weight loss interventions are crucial for managing hypertension in obese individuals.

Purpose of the Study:

  • To investigate the relationship between changes in blood pressure and fat distribution after a low-calorie diet in obese hypertensive women.
  • To determine if weight loss or reduction in visceral fat is the primary driver of blood pressure reduction.
  • To explore the role of glucose metabolism in this relationship.

Main Methods:

  • A 12-week, 1200-kcal low-calorie diet intervention was conducted in 26 obese hypertensive women.

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  • Intra-abdominal visceral fat and subcutaneous fat areas were measured using computed tomography at the umbilical level.
  • Blood pressure, body weight, body mass index, fasting plasma glucose, and glucose tolerance were assessed before and after the diet.

    • Main Results:

    • Subjects achieved a mean weight loss of 9.4 kg and a significant reduction in mean blood pressure (112 to 101 mm Hg).
    • The ratio of visceral to subcutaneous fat area significantly decreased (0.56 to 0.45).
    • Blood pressure reduction was correlated with decreased visceral fat area and improved glucose tolerance, but not with overall weight loss or BMI change.

    Conclusions:

    • A decrease in intra-abdominal visceral fat, rather than solely body weight reduction, is associated with reduced blood pressure in obese hypertensive women.
    • Improved glucose tolerance may be a key mechanism linking visceral fat reduction to blood pressure lowering.
    • Targeting visceral fat reduction through dietary interventions may be an effective strategy for managing hypertension in obese populations.