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Prolongation of Q-I interval in atrial septal defect
Insights
The Q-I interval is prolonged in patients with atrial septal defect (ASD), correlating with defect size and age. Surgical closure of ASD significantly shortens this interval, indicating a left-to-right shunt effect.
Area of Science:
- Cardiology
- Electrophysiology
- Congenital Heart Disease
Background:
- The Q-I interval, a measure of ventricular conduction, is crucial in assessing cardiac function.
- Atrial septal defect (ASD) can impact cardiac hemodynamics and electrical properties.
- Understanding factors influencing the Q-I interval in ASD is important for clinical management.
Purpose of the Study:
- To investigate the Q-I interval in patients with ostium secundum atrial septal defect (ASD).
- To compare the Q-I interval in ASD patients with healthy individuals and those with mitral stenosis.
- To identify factors affecting the Q-I interval in ASD and its changes after surgical correction.
Main Methods:
- Electrocardiographic assessment of the Q-I interval.
- Comparison between 55 ASD patients, 60 healthy controls, and 37 mitral stenosis patients.
- Correlation analysis with defect size, age, heart rate, blood pressure, and right heart catheterization data.
- Evaluation of Q-I interval changes post-surgical ASD closure.
Main Results:
- The Q-I interval was significantly prolonged in ASD patients compared to healthy controls.
- ASD patients exhibited a shorter Q-I interval than mitral stenosis patients.
- Q-I interval in ASD correlated significantly with septal defect size and patient age.
- No significant correlation was found with heart rate, blood pressure, or right heart catheterization parameters.
- Surgical closure of ASD resulted in a significant shortening of the Q-I interval.
Conclusions:
- A left-to-right shunt at the atrial level, characteristic of ASD, leads to Q-I interval prolongation.
- Septal defect size and patient age are key factors influencing the Q-I interval in ASD.
- The Q-I interval serves as a potential indicator of hemodynamic changes in ASD and responds positively to surgical intervention.
Abstract:
The present paper is concerned with Q-I interval and factors affecting this interval in 55 patients with atrial septal defect of ostium secundum type (ASD) in comparison with the interval in 60 healthy individuals and 37 patients with mitral stenosis. The results obtained are as follows: 1) Q-I interval was significantly greater in patients with ASD than in healthy individuals, and less than in patients with mitral stenosis. 2) The Q-I interval in ASD showed significant correlations with size of septal defect and age, but no correlation with other variables such as heart rate, blood pressure, and right heart catheterization data. 3) The interval was significantly shortened following the surgical closure of ASD. These findings suggest that left-to-right shunt at atrial level leads to prolongation of Q-I interval. Mechanisms for these results were discussed.