Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methods for microelectrode-guided posteroventral pallidotomy

A Lozano1, W Hutchison, Z Kiss

  • 1Division of Neurosurgery, Toronto Hospital (Western Division), Ontario, Canada.

Journal of Neurosurgery
|February 1, 1996
PubMed
Summary

This study details methods for precisely locating brain targets using microelectrodes for deep brain stimulation. These techniques aid in selecting optimal sites for treating Parkinson's disease with stereotactic posteroventral pallidotomy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Bacteroidetes</i> promote hepatocellular carcinoma progression and resistance to immunotherapy.

bioRxiv : the preprint server for biology·2025
Same author

Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography.

Nature medicine·2025
Same author

Dentine surface morphology according to caries removal method and subsequent acid etching.

European journal of paediatric dentistry·2024
Same author

Neutrino-Induced Coherent π^{+} Production in C, CH, Fe, and Pb at ⟨E_{ν}⟩∼6  GeV.

Physical review letters·2023
Same author

Simultaneous Measurement of Muon Neutrino ν_{μ} Charged-Current Single π^{+} Production in CH, C, H_{2}O, Fe, and Pb Targets in MINERvA.

Physical review letters·2023
Same author

Simultaneous Measurement of ν_{μ} Quasielasticlike Cross Sections on CH, C, H_{2}O, Fe, and Pb as a Function of Muon Kinematics at MINERvA.

Physical review letters·2023

Area of Science:

  • Neurosurgery
  • Neurology
  • Stereotactic Surgery

Background:

  • Accurate localization of deep brain structures is crucial for effective stereotactic surgery.
  • The posteroventral globus pallidus is a key target for treating movement disorders like Parkinson's disease.

Purpose of the Study:

  • To describe and validate microelectrode recording and stimulation techniques for precise localization of the posteroventral globus pallidus.
  • To identify surrounding critical neuroanatomical structures.

Main Methods:

  • Utilizing microelectrodes for single-unit activity recording and microstimulation in the human pallidum.
  • Mapping characteristic cell types and functional responses (visual, motor, sensory) during electrode trajectory.
  • Identifying the optic tract and internal capsule through evoked responses.

Related Experiment Videos

Main Results:

  • Precise determination of the locations of distinct cell types within the external and internal segments of the globus pallidus.
  • Accurate identification of the optic tract and internal capsule via microstimulation.
  • Demonstrated utility of the technique for guiding lesion placement.

Conclusions:

  • Microelectrode-based localization provides accurate anatomical and functional targeting for posteroventral globus pallidus interventions.
  • This method is essential for optimizing lesion placement in stereotactic posteroventral pallidotomy for Parkinson's disease.
  • The described techniques enhance the safety and efficacy of surgical treatments for movement disorders.