Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hyperoxaluria type 2

M A Mansell1

  • 1St Peter's Hospital, London, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute oxalate nephropathy causing late renal transplant dysfunction due to enteric hyperoxaluria.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008
Same author

Still an abhorrent practice?

The Medico-legal journal·2007
Same author

Legal aspects of renal failure.

The Medico-legal journal·2005
Same author

The ethics of rewarded kidney donation.

BJU international·2004
Same author

Strange days indeed.

The Medico-legal journal·2002
Same author

Research governance--global or local?

The Medico-legal journal·2001
Same journal

Correction to: Hyponatraemia-treatment standard 2024.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Effect of Semaglutide on Measured vs Estimated Glomerular Filtration Rate.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Beyond Diffusion and Convection: Is Adsorption the Third Dimension of Dialysis?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Pivotal Clinical Trials in C3 Glomerulopathy: answers and remaining uncertainties.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Urinary protein vs albumin for assessing kidney failure risk in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Systolic blood pressure and albuminuria reduction mediate cardiovascular benefits of finerenone in T2 diabetes and CKD.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
See all related articles

Primary hyperoxaluria type 2 (PH2) is a rare genetic disorder causing hyperoxaluria and L-glyceric aciduria due to D-glycerate dehydrogenase deficiency. Less is known about PH2 compared to PH1, with uncertainties in its frequency, clinical course, and management.

Area of Science:

  • Biochemistry
  • Genetics
  • Metabolic Disorders

Background:

  • Primary hyperoxaluria type 1 (PH1) results from hepatic peroxisomal alanine:glyoxylate aminotransferase deficiency.
  • PH1 has hundreds of documented cases since 1925.
  • Primary hyperoxaluria type 2 (PH2) is significantly rarer, with only 22 reported patients since 1968.

Observation:

  • PH2 is characterized by hyperoxaluria and L-glyceric aciduria.
  • The underlying cause of PH2 is a deficiency in D-glycerate dehydrogenase/glyoxylate reductase.
  • Limited information exists regarding PH2 compared to PH1.

Findings:

  • PH2 is caused by D-glycerate dehydrogenase/glyoxylate reductase deficiency.
  • PH2 presents with hyperoxaluria and L-glyceric aciduria.

Related Experiment Videos

  • The rarity of PH2 contributes to knowledge gaps.

    • Implications:

    • Further research is needed to understand PH2 frequency and clinical spectrum.
    • Optimal management strategies for PH2 require further investigation.
    • Understanding PH2 biochemical pathways is crucial for potential therapeutic targets.