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Related Experiment Videos

Cell-adhesion molecules, glucocorticoids and long-term-memory formation

S P Rose1

  • 1Brain and Behaviour Research Group, Open University, Milton Keynes, UK.

Trends in Neurosciences
|November 1, 1995
PubMed
Summary

Long-term memory formation requires glycoprotein synthesis, specifically cell-adhesion molecules (CAMs), after training. Corticosterone enhances memory retention by influencing these glycoprotein levels, suggesting a target for memory disorder treatments.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cognitive Science

Background:

  • Long-term memory consolidation involves persistent changes in synaptic connections.
  • Glycoprotein synthesis, particularly cell-adhesion molecules (CAMs) like neural CAM (NCAM) and Ll, is crucial for memory retention 5-8 hours post-training.
  • Weak learning events fail to trigger this glycoprotein synthesis, resulting in memory loss.

Purpose of the Study:

  • To investigate the role of glycoprotein synthesis in memory consolidation.
  • To explore the influence of corticosterone on memory retention and its relation to glycoprotein synthesis.
  • To identify potential pharmacological targets for memory impairment.

Main Methods:

  • Administering training tasks of varying strengths.

Related Experiment Videos

  • Using antibodies to block neural CAM and Ll function post-training.
  • Administering corticosterone and steroid-receptor antagonists.
  • Assessing memory retention and glycoprotein synthesis levels.

    • Main Results:

    • Enhanced synthesis of glycoprotein CAMs (NCAM, Ll) 5-8 hours post-training is essential for memory retention.
    • Blocking CAMs or weak training inhibits this synthesis and leads to amnesia.
    • Corticosterone administration enhances retention of weak learning by mediating 'second-wave' glycoprotein synthesis.
    • Nootropic drugs like piracetam show effects only on long-term retention and are ineffective in adrenalectomized animals.

    Conclusions:

    • Glycoprotein cell-adhesion molecules are critical mediators of memory consolidation.
    • Glucocorticoids, like corticosterone, interact with glycoprotein synthesis pathways to modulate memory.
    • The interplay between glucocorticoids and glycoproteins presents a potential therapeutic avenue for neurodegenerative memory loss.