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Updated: Jul 30, 2026
14:10
Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
Published on: July 4, 2007
Falciparum malaria, imported into The Netherlands, 1979-1988. I. Epidemiological aspects
1Unit for Tropical Medicine, Royal Tropical Institute, Amsterdam, The Netherlands.
Tropical and Geographical Medicine
|January 1, 1995
Summary
Chloroquine resistance in Plasmodium falciparum malaria is widespread, especially in non-immune travelers from sub-Saharan Africa. Monitoring drug resistance in travelers aids in predicting resistance evolution and guiding prophylaxis strategies.
Area of Science:
- Tropical Medicine
- Infectious Diseases
- Parasitology
Background:
- Falciparum malaria remains a significant global health concern.
- Drug resistance in Plasmodium falciparum complicates malaria treatment and prevention.
- Sub-Saharan Africa is a major region for malaria transmission and drug resistance emergence.
Purpose of the Study:
- To prospectively investigate chloroquine resistance in Plasmodium falciparum malaria.
- To assess the impact of chemoprophylaxis on malaria infection and drug resistance.
- To monitor the spread of drug resistance and inform public health strategies.
Main Methods:
- Prospective investigation of 427 patients with falciparum malaria from 1979-1988.
- Evaluation of chloroquine sensitivity and resistance in non-immune and semi-immune patients.
- Recording and verification of chemoprophylaxis history and serum drug concentrations.
Main Results:
- Chloroquine resistance confirmed in 67% of evaluable non-immune patients infected in sub-Saharan Africa.
- Adequate chemoprophylaxis was associated with a high prevalence of resistant Plasmodium falciparum strains.
- Spread of drug resistance from East Africa to other regions was observed during the study period.
Conclusions:
- Monitoring drug-resistant falciparum malaria in travelers is crucial for predicting resistance evolution.
- Surveillance of drug resistance in travelers aids in providing optimal treatment and chemoprophylaxis advice.
- Chloroquine resistance is a significant challenge in managing falciparum malaria, particularly in travelers from endemic areas.
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